I highly recommend all players use the External Item Descriptions mod so you don't have to manually look up the effect of every item you find.ĭefeat Satan 5 times to unlock The Negative and Isaac 5 times to unlock The Polaroid. Achievements can then be unlocked even with mods and the debug console enabled. Let me know if there's any other big progression milestones that I should include.ĭefeat Mom 1 time (without mods or the debug console enabled) to unlock the Womb floors and Mom's Heart. So I decided to make a quick(ish) guide, mostly for my future self tbh. I'm starting my 3rd save file and still can't remember how a lot of early progression milestones are unlocked, and it's super obtuse trying to find it on the wiki. ![]() SPOILER WARNING if you're a new player who cares about that kind of thing.
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